Gli3 mutations cause limb development disorders, such as Greig cephalopolysyndactyly syndrome (GCPS) [22], Pallister-Hall syndrome (PHS) [23], postaxial polydactyly type A (PAP-A) [24] and preaxial polydactyly type IV [25]. The gene discussed is GLI3; the disease is Greig cephalopolysyndactyly syndrome.