Compared to the first quintile, the age- and sex-adjusted OR for ischemic stroke was greater in the third, fourth, and fifth quintiles (the third quintile: OR 3.54, 95%CI 1.17-10.67, p = 0.02; the fourth quintile: OR 4.48, 95%CI 1.53-13.09, p = 0.006; the fifth quintile: OR 4.70, 95%CI 1.62-13.61, p = 0.004), while there was no association between quintile of resistin and CVD. The gene discussed is RETN; the disease is ischemic stroke.