SMAD7 and colorectal carcinoma: Three GWA studies of CRC have so far been reported and 10 independent loci shown conclusively to be associated with CRC risk: 8q24.21, 11q23, 18q21.1 (SMAD7), 8q23.1 (EIF3H), 15q (GREM1), 19q13.1 (RHPN2), 20q12.3, 14q22.2 (BMP4), 16q22.1 (CDH1) and 10p14 (Tomlinson et al, 2005, 2007; Broderick et al, 2007; Zanke et al, 2007; Houlston et al, 2008; Jaeger et al, 2008; Tenesa et al, 2008).