Although our recent studies suggest GSK-3 as an important factor of NF-κB-mediated cancer cell survival and proliferation in pancreatic cancer and CLL (Ougolkov et al, 2005, 2007), the role of GSK-3 in the proliferation, survival and chemoresistance of RCC is unknown. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.