Previously, we showed that inhibition of GSK-3 resulted in apoptosis induction through decreased expression of NF-κB target genes Bcl-2 and XIAP in chronic lymphocytic leukaemia (CLL) and pancreatic cancer cells (Ougolkov et al, 2005, 2007). The gene discussed is NFKB1; the disease is familial pancreatic carcinoma.