As GSK-3β has a positive role in expression of certain NF-κB-regulated genes (Hoeflich et al, 2000; Ougolkov et al, 2005, 2007), we investigated whether inhibition of GSK-3 affects NF-κB-mediated expression of Bcl-2 and XIAP in renal cancer cells. The gene discussed is BCL2; the disease is renal carcinoma.