Bevacizumab, a humanised monoclonal antibody against VEGF (Avastin, Genentech Pharmaceuticals, South San Francisco, CA, USA), was originally reported to achieve dramatic radiographic responses when combined with the topoisomerase-1 inhibitor irinotecan among recurrent GBM patients (Stark-Vance, 2005). The gene discussed is VEGFA; the disease is glioblastoma.