Light-induced retinal damage in rats involvesWOX1 phosphorylation at Tyr33 and subsequent translocation to the mitochondria andnuclei [2].In a Parkinsonism model, MPP+ (1-methyl-4-phenylpyridinium) wasshown to stimulate an initial increase in the complex formation of WOX1 and JNK1,followed by dissociation, in the cortical and striatal neurons in rats, suggestingthat the dissociation is needed for WOX1 to exert neuronal death [3]. The gene discussed is WWOX; the disease is Parkinsonism.