TP53 and acute lymphoblastic leukemia: 1). Conversely, down-regulation of p53-R175H by siRNA significantly attenuated the invasive potential of KLE cells (Figure. 2). Previous study showed p53-R175H can endow p53-negative T-ALL cells with the capacity to disseminate, and induce lymphohematopoietic metastatic potential and tissue invasiveness in SCID mice [27].