Because dendritic spines are the most common target of glutamatergic terminals [57], and because density of spines on layer 3 pyramidal cells has been found to be decreased by ~20% in schizophrenia [58], it would appear that our finding of reduced vGluT1 immunoreactivity reflects, at least in part, a loss of axon terminals. This evidence concerns the gene SLC17A7 and schizophrenia.