Increasing evidence suggests that the subset of GABA cells that contain the calcium buffering protein parvalbumin (PV), which exhibit fast-spiking firing properties and target the perisomatic (basket cells) and axo-axonic (chandelier cells) compartments of pyramidal neurons [24,25], are functionally disturbed in schizophrenia [17,26], and these cells express NR2A [27-29]. This evidence concerns the gene GRIN2A and schizophrenia.