Despite the small number of cases, they found CD10 expression in 80% of invasive carcinomas and also proved that the staining intensity for the high-grade group (including invasive carcinoma, high-grade papillary urothelial carcinoma, and carcinoma in situ) was statistically higher than that of the low-grade group (including low-grade papillary urothelial carcinoma, papillary urothelial neoplasm of low malignant potential and normal urothelium). This evidence concerns the gene MME and in situ carcinoma.