The present data thus provide further support for the role of oxidative stress in diabetes-induced diaphragm dysfunction by identifying eight genes related to oxidoreductase activity (Cyp2e1, Fmo3, Cryl1, Lox, Cp, Decr1, Aox1, Por) with increased expression in diabetic compared with normal diaphragm. The gene discussed is CRYL1; the disease is diabetes mellitus.