Many proteins involved in key signaling pathways of CRC, such as members of the Wnt/β-catenin and phosphatidylinositol-3-kinase (PI-3-K) pathways, KRAS, p53, extracellular matrix regulators as well as epithelial-mesenchymal transition (EMT) transcription factors [10], are altered and seem to be affected by miRNA regulation in CRC (summarized in Fig. 1). The gene discussed is KRAS; the disease is colorectal carcinoma.