Additionally, our in vivo data indicate that a distinct HDAC "high" subgroup is likely to show strong RelA/p65 nuclear translocation/activity, which is of particular interest in pancreatic carcinoma, since activation of the NF-κB pathway is associated with pancreatic cancer development and progression and is an adverse prognosticator for this entity [18]. The gene discussed is NFKB1; the disease is familial pancreatic carcinoma.