FOXP3 and chronic obstructive pulmonary disease: When analyzing the groups based on their current smoking status, COPD smokers had a higher percentage of CD4+CD25highFoxp3+ T cells than healthy smokers (p = 0.049, Figure 7D), which was also true for the CD4+CD25+Foxp3+ T cells (trend (p = 0.065), Figure 7B).