Indeed, it has been recently shown that ADARs activity can be influenced by the presence of a regulatory network of proteins and/or RNAs that could modulate their function.5,18,47–50BLCAP was first identified in a screen for genes contributing to the invasive phenotype of renal, cervical and bladder cancer (TCC) as its transcript was found to be downregulated in these tumors.28,30,31 Furthermore, herein, we found that BLCAP edited isoforms are reduced in different type of cancers. The gene discussed is BLCAP; the disease is tarsal-carpal coalition syndrome.