TP53 and carcinoma: Based on the fact that B cell lymphomas, carcinomas and sarcomas occurred infrequently in p53−/−p73+/− mice and even less so in p53−/−p73−/− (DKO) animals, our data imply that tumor suppressive properties of p73 are highly dependent on cellular context, wherein p73 plays a major p53-dependent role in T cell development and neoplasia.