In vitro, we have observed increases in CD54 and CCR7 (10-fold and 1.4-fold increase in MFI, respectively) following 48 hr incubation of purified B cells with CP-870,893 (data not shown), which supports a hypothesis that CP-870,893 activation might drive circulating B cells into tumor, lymph nodes, or spleen. Here, ICAM1 is linked to neoplasm.