TRIB3 and neoplasm: Trib3 is a human homologue of Drosophila tribbles 3, which regulates cell growth, differentiation, oogenesis and metabolism by promoting ubiquitination-dependent degradation of other proteins, interacts with several transcriptional factors and is expressed in several tumours (Mata et al, 2000; Bowers et al, 2003; Du et al, 2003; Koo et al, 2004; Boudeau et al, 2006; He et al, 2006; Koh et al, 2006; Matsushima et al, 2006; Ord et al, 2007; Kato and Du, 2007; Xu et al, 2007; Yao and Nyomba, 2008).