In addition, according to the analysis for the association between B7-H4 gene polymorphisms and clinical presentations, we found that the rs10754339 GG genotype was significantly associated with lymph node metastasis and PR status, and the G allele and the AG genotype were respectively associated with lymph node metastasis and ER status. The gene discussed is ESR1; the disease is metastatic malignant neoplasm in the lymph nodes.