CYP3A4 and prostate cancer: For example, the CY3A4-V gene variant and prostate cancer are reported to be substantially less common among European American than African American (AA) men; Kittles et al. studied 688 AAs and found that a strongly significant association at CYP3A4-V for prostate cancer became a non-significant signal after including ten ancestry informative markers (AIMs) [19].