Furthermore, expression of IGFBP3 is induced by a number of growth inhibitory and pro-apoptotic agents, including p53 [18,19], TGF-β [20,21], retinoids [20], TNF-α [22], vitamin D [23], and celecoxib [24], suggesting that IGFBP3 may, in part, mediate their anti-tumor effects. This evidence concerns the gene IGFBP3 and neoplasm.