Subjects with IGT and newly diagnosed type-2 diabetes were similar in age and had significantly higher fasting and post-lunch blood glucose (P < 0.0001, P < 0.0001, respectively), and not significantly higher fasting and post-lunch serum insulin, C-peptide, abnormal lipid profile, and HOMA-IR levels compared with nondiabetic subjects. Here, INS is linked to type 2 diabetes mellitus.