The test for IgA antibodies against tTGA is proven to be highly accurate, the ELISA that has less potential for interpretational error and thus, represents an improvement over the EMA that relies on indirect immunofluorescence, thus, carrying an inherent intraobserver subjectivity in interpretation of the test.[11] It seems that the lower prevalence of CD in patients with T1DM found in previous studies in Iran might be underestimates of the true prevalence in the population. This evidence concerns the gene CD79A and type 1 diabetes mellitus.