We also showed that IL-2 at priming enhances the ability of CD8+ T cells to eradicate tumor by producing greater quantities of interferon-γ and granzyme B. These findings takes us one step closer to the understanding of how CD4+ T cells help CD8+ T-cell activation and define the temporal function of IL-2 in regulation of a CD8+ T cell response. Here, GZMB is linked to neoplasm.