To determine if the level of p-STAT-3 positive cells in the glioma correlated to the mean percent of PBMCs displaying p-STAT-3, we performed a subgroup analysis in which glioma specimens were stained with an antibody against p-STAT-3 and compared to the same patient's percentage of p-STAT-3 positive PBMCs. The gene discussed is STAT3; the disease is central nervous system cancer.