NFKB1 and neoplasm: Indeed, Hanahan and Weinberg identified the six hallmarks that characterized tumor cells (Self-Sufficiency in Growth Signals, Insensitivity to Anti-growth Signals, Evading Apoptosis, Limitless Replicative Potential Sustained Angiogenesis, Tissue Invasion and Metastasis) [16,17] and most of the genes that regulate such effects are under the transcriptional control of NFκB.