FOXC1 and Axenfeld-Rieger syndrome: Mutations of PITX2 result in Rieger’s syndrome (anterior segment abnormalities, glaucoma, tooth anomalies, umbilical stump abnormalities); mutations of FOXC1 result in Rieger’s syndrome (type 3); mutations of FKHL7 cause anterior segment anomaly with glaucoma (abnormal iridocorneal angle differentiation, iris stromal hypoplasia, and elevated intraocular pressure/glaucoma) [1,14–17].