NR2E3 and retinal disorder: We hypothesize that (i) a lack of or reduced NR2E3 activity in developing retina of retinopathy patients does not allow functional maturation of rod photoreceptors; (ii) enhanced S-cone function is the result of de-repression of S-cone genes in such photoreceptors; (iii) these abnormal rod photoreceptors (expressing cone genes) degenerate with time; and (iv) different clinical phenotypes may reflect distinct impact of mutations on the transcriptional regulatory function of NR2E3.