Because gemcitabine is used to treat a variety of solid tumors including pancreatic cancer, in order to validate this association obtained using lymphoblastoid cell lines, we selected two pancreatic tumor cell lines to perform siRNA knock down of three selected genes (MGMT, VAV3 and GPM6A) with expression levels that were associated with either or both of the rs3797418 and rs6082527 SNPs. The gene discussed is VAV3; the disease is pancreatic neoplasm.