TLR2 and infection: Interestingly, comparison of TLR expression on cells of the immune system between urban European neonates and Gabonese neonates who in a semi urban area are exposed to high burden of infections, indicated a significantly lower expression TLR-2 on Gabonese cells, suggesting that there is a very early down regulation of TLRs possibly as a result of in utero exposure to micro organisms and parasites [29].