AKT1 and leukemia: Additionally, in leukemia and other hematopoietic disorders, the Akt, Stat and extracellular signal-regulated kinase (ERK) signaling pathways are frequently activated by upstream mutations of cytokine receptors, aberrant chromosomal translocations as well as other genetic problems [15], resulting in suppression of apoptosis and deregulation of proliferation [16].