Apart from these findings, our study shows that Smac-mimetics as a single agent induce neither cell death nor NF-κB activation in androgen-independent prostate cancer cells, suggesting that both apoptosis and NF-κB failed to be activated by the Smac-mimetic alone in chemo- or radioresistant cells with constitutively active NF-κB signaling. This evidence concerns the gene NFKB1 and prostate cancer.