Among the 4-hour glucose-insulin index we found: 54 patients (66.7%) with hypoglycemia, relative in 35 (64.8%) and in absolute value in 29 (53.7%), 45 subjects (55.5%) with hyperinsulinemia, 22 (27.2%) with hyperglycemia, 10 (12.3%) with glucose intolerance and 1 (1.2%) with hypoinsulinemia, when more than one alteration could be found in the same test. This evidence concerns the gene INS and Hypoglycemia.