TRAF3 is an adapter molecule that is required for the induction of type I IFN and anti-inflammatory cytokine interleukin-10 (IL-10), but is dispensable for expression of pro-inflammatory cytokines in response to viral infection and TLR ligation in bone marrow-derived macrophages (BMMs), plasmacytoid dendritic cells (pDCs), and murine embryonic fibroblasts (MEFs) [31],[32]. The gene discussed is IL10; the disease is viral infectious disease.