To further explore the consequences of blocking CXCR2 signaling early following infection, neuroinflammation was assessed by H&E staining of brains from JHMV-infected mice treated with either anti-CXCR2 or control sera at day 9 p.i. Such analysis revealed limited inflammatory cell infiltration, as demonstrated by an overall reduction in the size of the meningeal and perivascular infiltrates (Figure 4D), compared to mice treated with control serum (Figure 4C). This evidence concerns the gene CXCR2 and infection.