SORL1 and Alzheimer disease: Eight of the 28 non-AD individuals had significant AD-associated neuropathology, i.e., Braak stages of III, IV or V. When SORL1 expression was evaluated as a function of Braak stage (Figure 4, Table 3), individuals who were cognitively intact but had moderate AD-like pathology (Braak stages of III-V) were found to have SORL1 expression levels more similar to the AD individuals (Braak VI) than the cognitively intact individuals with little AD-like pathology (Braak stages 0-II).