In the present work, mean IMD assessed by CD105 was not significantly different between the entire samples of malignant tumors that did or not metastasized, and even all of the PLGA and more than half of the ACC that metastasized did not present CD105 positive vessels, suggesting that angiogenesis is neither an absolute determinant nor required for acquisition of metastatic phenotype in these salivary gland tumors. This evidence concerns the gene ENG and cancer.