They are well known to activate the ubiquitous transcription factor NF-κB, which leads to further production and upregulation of proinflammatory cytokines and enzymes such as Cox-2 and MMPs, which in turn produce prostaglandins and degrade ECM macromolecules leading to cartilage degradation and further joint inflammation [40]. Here, NFKB1 is linked to Arthritis.