Although the scoring criteria of UCCC for stratification of NSCLC patients with EGFR FISH assay effectively copes with complexity of EGFR gene amplification mechanisms, it doesn't always allow to discriminate between real gene amplification and high level polysomy, particularly when almost the same number of centromere 7 and EGFR gene signals is present. Here, EGFR is linked to non-small cell lung carcinoma.