It may be relevant that HLA-G alleles have been associated in Jewish patients with Pemphigus Vulgaris, an idiopathic blistering disorder characterised by loss of cell-cell adhesion between keratinocytes [31], and that HLA-G has been implicated in the aetiology of asthma in Hutterites [32]. This evidence concerns the gene HLA-G and pemphigus vulgaris.