EIF2AK2 and viral infectious disease: Virus infections induce the production of type I interferons (IFN-α/β), which through the IFN receptor-mediated JAK-STAT signal transduction pathway [7] induce OAS and PKR genes encoding the key antiviral enzymes 2′5′-oligoadenylate synthetase (2′5′AS) and proteinkinase p68 (PKR).