CD80 and type 1 diabetes mellitus: IFN-α has been detected in residual pancreatic islets from deceased patients with recent-onset or long-term type 1 diabetes [20, 21] and IFN-α was reported to be a potential mediator of type 1 diabetes induced by poly(I:C) in C57BL/6 mice expressing the B7.1 costimulatory protein in islets [52].