REST and cancer: These observations imply that, because of their broad range of effects on DNA methylation, chromatin remodeling, and gene modulation, REST and CoREST may be key targets for epigenetic reprogramming not only in cancer but also in many other glial diseases, particularly as epigenetic remodeling is known to be important for modulating progressive stages of OL lineage maturation [69], [92], [93], [94].