IRF1 and demyelinating disease: For example, we found genes from genomic loci linked to multiple sclerosis (e.g., Abca8a, Il2ra, Irf1, Prkca, Slc1a3, Tap2, and Ttyh2), the most common cause of central nervous system demyelinating disease, and multisystem atrophy (e.g., Tppp), a primarily glial disorder that is related to Parkinson's disease and characterized by deregulation in the metabolism of myelin basic protein and tubulin polymerization promoting protein [91].