Eno2-ΔGR/EGFP bigenic mice spent less time and visited the open arms and their extremities less often than control littermates (Figure 6A–C, A: t17 = 2.993 p<0.0087; B: t17 = 2.128 p<0.049; C: t17 = 2.273 p<0.037) suggesting an increase in anxiety-related behaviors. The gene discussed is ENO2; the disease is Anxiety.