Comparisons of serum S100A6 concentration from tumor-bearing mice and saline-injected controls revealed that, as early as 9 days p.i., there was significantly greater serum S100A6 concentration in the tumor-bearing mice, well before any identifiable tumor masses were present; the significant differential serum S100A6 level persisted through day 15 to day 21 p.i. (Figure 6B). Here, S100A6 is linked to neoplasm.