The Pediatric Crohn's Disease Activity Index (PCDAI) [22] was used as an objective clinical parameter to investigate a possible pathogenic relevance for the proinflammatory responses to HSP60/65 epitopes and determine whether there was a statistical correlation between the induction of a proinflammatory response by specific HSP60/65-derived peptides and disease severity. The gene discussed is HSPD1; the disease is Crohn disease.