EGFR and Familial prostate cancer: Regulation of EGFR expression by androgens is shown to be at the transcriptional level, both in normal prostate tissue and prostate cancer (PCa) cell lines (Brass et al, 1995; Ravenna et al, 1995; Nishi et al, 1996; Itoh et al, 1998; Schwartz et al, 1998; Hammarsten et al, 2007; Pignon et al, 2009).