However, in PCa, EGFR expression is upregulated, suggesting an increased expression in advanced cancer (Di Lorenzo et al, 2002), and correlated with a high Gleason score and tumour progression from an androgen-dependent to an androgen-independent state (Sherwood and Lee, 1995; Syed and Tolcher, 2003). The gene discussed is EGFR; the disease is posterior cortical atrophy.