In the ARRIVE (Abatacept Researched in RA patients with an Inadequate anti-TNF response to Validate Effectiveness) trial, which aimed to assess the safety and tolerability in patients with active RA who had failed up to three anti-TNFα agents, the mean reduction in DAS28 at 6 months was -2.0 from baseline. This evidence concerns the gene TNF and rheumatoid arthritis.