ELN and spinal stenosis: Increased MMP activity can result in several pathologic conditions such as arthritis, aneurysm, atherosclerosis, mid-dermal elastolysis, Marfan syndrome and intervertebral disc degeneration and herniation.9-15) These findings suggest that MMPs might also act as a mediator of elastin degradation and fibrosis of the ligamentum flavum, which occurs in spinal stenosis.