Higher expression in RA compared with controls was found for CD14 antigen, defensin α-1 and α-3 (DEFA), fatty-acid-Coenzyme A ligase, long-chain 2 (FACL), ribonuclease 2 (RNASE2), S100 calcium-binding protein A8, and A12 (S100A8 and S100A12). This evidence concerns the gene S100A8 and rheumatoid arthritis.