Enhanced expression of proteins in SSc compared with IPF was demonstrated for α1-B glycoprotein, complement C3β, α1-antitrypsin, and haptoglobin β. Proteins with enhanced expression in SSc compared with sarcoidosis included prothrombin, thioredoxin, peroxisomal antioxidant enzyme (AOPP), calgranulin, and thioredoxin peroxidase 2. Here, TXN is linked to systemic sclerosis.