Overexpression of miR-125a and miR-125b decreased ERBB2 and ERBB3 mRNA and protein levels, inhibited phosphorylation of ERK1/2 and AKT, and inhibited the anchorage-independent growth of ERα-negative/ErbB2-overexpressing SKBR3 breast cancer cells [195]. This evidence concerns the gene ESR1 and breast carcinoma.