In this respect, there is a long list of predicted miRNAs (i.e. from DIANA-microT, miRanda, TargetScanS algorithms) that may target the 3'UTR of APP, including let-7i, miR-15, -26, -29, -93, -101, -106, and miR-181 which are reportedly down-regulated in AD brain [96, 99]. The gene discussed is APP; the disease is Alzheimer disease.